• 咨询热线
    客服服务热线 13671568941/15317326293
  • 在线咨询
  • 微信客服
    微信客服
  • 公众号
    扫码关注公众号

USP25 and 28 inhibitor AZ-2

CAS No. 2165322-95-0

USP25 and 28 inhibitor AZ-2 ( USP25/28 inhibitor AZ2 )

产品货号. M13456 CAS No. 2165322-95-0

USP25 and 28 inhibitor AZ-2 is apotent, selective, dual USP25/28 inhibitor with IC50 of 0.9/0.9 uM, respectively.

纯度: >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
规格 价格/人民币 库存 数量
5MG ¥7857 有现货
50MG ¥16038 有现货
100MG ¥20250 有现货
200MG 获取报价 有现货
500MG 获取报价 有现货
1G 获取报价 有现货

生物学信息

  • 产品名称
    USP25 and 28 inhibitor AZ-2
  • 注意事项
    本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
  • 产品简述
    USP25 and 28 inhibitor AZ-2 is apotent, selective, dual USP25/28 inhibitor with IC50 of 0.9/0.9 uM, respectively.
  • 产品描述
    USP25 and 28 inhibitor AZ-2 is apotent, selective, dual USP25/28 inhibitor with IC50 of 0.9/0.9 uM, respectively; shows a high degree of selectivity over other deubiquitinases (USP4,7 etc.); demonstrates target engagement against both USP25 and USP28 in cells, elicits modulation of both the total levels and the half-life of the c-Myc oncoprotein in cells, and also induces apoptosis and inhibits cell viability in a range of cancer cell lines.
  • 同义词
    USP25/28 inhibitor AZ2
  • 通路
    Proteasome/Ubiquitin
  • 靶点
    DUB
  • 受体
    DUB
  • 研究领域
    ——
  • 适应症
    ——

化学信息

  • CAS Number
    2165322-95-0
  • 分子量
    420.23
  • 分子式
    C17H17BrF3NO3
  • 纯度
    >98% (HPLC)
  • 溶解度
    10 mM in DMSO
  • SMILES
    C1=CC(=CC(=C1)OC(F)(F)F)COC2=C(C=C(C=C2)Br)CNCCO
  • 化学全称
    2-((5-bromo-2-((3-(trifluoromethoxy)benzyl)oxy)benzyl)amino)ethan-1-ol

运输与储存

  • 储存条件
    (-20℃)
  • 运输条件
    With Ice Pack
  • 稳定性
    ≥ 2 years

参考文献

1. Wrigley JD, et al. ACS Chem Biol. 2017 Nov 28. doi: 10.1021/acschembio.7b00334.
产品手册
关联产品
  • FT-671

    FT-671 is a novel potent, specific, non-covalent USP7 inhibitor with Kd of 65 nM (USP7 catalytic domain).

  • LDN 91946

    LDN 91946 is a selective, uncompetitive ubiquitin C-terminal hydrolase-L1 (UCH-L1) inhibitor with Ki of 2.8 uM.

  • USP7-IN-4

    (R)-USP-IN-4 is a highly potent, selective, allosteric USP7 inhibitor with IC50 of 6 nM in FP assays.